Edson Antunes Selected Research

4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acid

12/2016	The soluble guanylyl cyclase activator BAY 60-2770 inhibits murine allergic airways inflammation and human eosinophil chemotaxis.
11/2014	Prolonged therapy with the soluble guanylyl cyclase activator BAY 60-2770 restores the erectile function in obese mice.
10/2014	The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model.
2/2014	The soluble guanylyl cyclase activator BAY 60-2770 ameliorates overactive bladder in obese mice.
1/2012	Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

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Edson Antunes Research Topics

Disease

21	Inflammation (Inflammations) 01/2021 - 05/2003
17	Obesity 01/2021 - 05/2011
11	Erectile Dysfunction 01/2020 - 05/2008
8	Asthma (Bronchial Asthma) 10/2020 - 01/2008
8	Overactive Urinary Bladder (Overactive Bladder) 01/2020 - 01/2012
7	Insulin Resistance 01/2018 - 04/2007
7	Body Weight (Weight, Body) 08/2017 - 01/2012
5	Pneumonia (Pneumonitis) 01/2021 - 11/2005
5	Sepsis (Septicemia) 04/2019 - 11/2011
5	Cardiovascular Diseases (Cardiovascular Disease) 02/2014 - 05/2006
4	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 02/2020 - 03/2013
3	Scorpion Stings 01/2020 - 01/2004
3	Edema (Dropsy) 01/2016 - 04/2013
3	Pulmonary Hypertension 10/2014 - 01/2004
3	Fibrosis (Cirrhosis) 07/2008 - 02/2002
3	Pancreatitis 07/2008 - 12/2005
3	Hypertension (High Blood Pressure) 04/2007 - 02/2002
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 01/2016
2	Thrombosis (Thrombus) 12/2020 - 02/2016
2	Weight Loss (Weight Reduction) 01/2020 - 12/2018
2	Hypoxia (Hypoxemia) 01/2020 - 02/2008
2	Cystitis 01/2018 - 01/2016
2	Bites and Stings (Sting) 01/2016 - 11/2008
2	Staphylococcal Infections 02/2015 - 11/2006
2	Vascular Diseases (Vascular Disease) 11/2014 - 01/2012
2	Pain (Aches) 11/2008 - 05/2003
2	Hypotension (Low Blood Pressure) 02/2008 - 01/2004
2	Allergic Rhinitis 07/2007 - 05/2002
2	Bradycardia 04/2007 - 10/2004
2	Hypertrophy 03/2006 - 02/2002
1	Premature Ejaculation 01/2022
1	Acute Lung Injury 01/2021

Drug/Important Bio-Agent (IBA)

13	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2017 - 02/2002
10	Soluble Guanylyl CyclaseIBA 01/2020 - 01/2007
7	Nitric Oxide Synthase (NO Synthase)IBA 03/2017 - 02/2002
6	NG-Nitroarginine Methyl Ester (L-NAME)IBA 03/2017 - 02/2002
5	ResveratrolIBA 10/2018 - 09/2016
5	4-(((4-carboxybutyl) (2- (5-fluoro-2-((4'-(trifluoromethyl) biphenyl-4-yl)methoxy)phenyl)ethyl) amino)methyl)benzoic acidIBA 12/2016 - 01/2012
5	Proteins (Proteins, Gene)FDA Link 01/2016 - 04/2007
4	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2012
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2012
4	mirabegronIBA 09/2019 - 03/2015
4	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2019 - 11/2011
4	VenomsIBA 01/2019 - 05/2003
4	AllergensIBA 09/2018 - 10/2012
4	Insulin (Novolin)FDA Link 12/2017 - 01/2012
4	Adrenergic Receptors (Adrenergic Receptor)IBA 08/2017 - 02/2002
4	salicylhydroxamic acid (SHAM)IBA 01/2017 - 07/2007
4	AntioxidantsIBA 10/2016 - 04/2013
4	3- (4- Amino- 5- cyclopropylpyrimidine- 2- yl)- 1- (2- fluorobenzyl)- 1H- pyrazolo(3,4- b)pyridineIBA 02/2015 - 03/2006
3	LipopolysaccharidesIBA 01/2021 - 11/2011
3	Cyclic GMPIBA 01/2018 - 05/2002
3	Captopril (Capoten)FDA LinkGeneric 02/2016 - 11/2008
3	Secretory Phospholipases A2IBA 01/2011 - 12/2005
2	AdipokinesIBA 01/2021 - 12/2018
2	Pyruvaldehyde (Methylglyoxal)IBA 01/2021 - 01/2020
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2020 - 05/2008
2	Antihypertensive Agents (Antihypertensives)IBA 01/2019 - 09/2014
2	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 01/2019 - 06/2016
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2018 - 01/2016
2	Cholinergic Agents (Cholinergics)IBA 03/2017 - 09/2011
2	pimagedine (aminoguanidine)IBA 03/2017 - 01/2013
2	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/2017 - 01/2008
2	AMP-Activated Protein KinasesIBA 09/2016 - 01/2013
2	Losartan (Cozaar)FDA LinkGeneric 02/2016 - 09/2014
2	Indomethacin (Indometacin)FDA LinkGeneric 01/2016 - 01/2004
2	arginine methyl esterIBA 01/2016 - 03/2006
2	Spider Venoms (Venom, Spider)IBA 01/2016 - 02/2002
2	BradykininIBA 10/2015 - 07/2008
2	Phosphodiesterase 5 InhibitorsIBA 10/2015 - 05/2008
2	Pharmaceutical PreparationsIBA 05/2015 - 01/2011
2	EnzymesIBA 01/2015 - 01/2012
2	Heme (Haem)IBA 11/2014 - 01/2012
2	Atenolol (Tenormin)FDA LinkGeneric 09/2014 - 02/2002
2	Staphylococcal enterotoxin AIBA 05/2013 - 11/2005
2	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2013 - 04/2010
2	CytokinesIBA 02/2011 - 01/2008
2	Peroxidase (Myeloperoxidase)IBA 02/2011 - 12/2005
2	Enterotoxins (Enterotoxin)IBA 09/2008 - 11/2006
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 11/2006
2	Heparin (Liquaemin)FDA LinkGeneric 01/2007 - 01/2004
2	Protamines (Protamine Sulfate)FDA Link 01/2007 - 01/2004
2	Propranolol (Inderal)FDA LinkGeneric 05/2006 - 02/2002
1	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 01/2022
1	Therapeutic UsesIBA 01/2022
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2022
1	InterleukinsIBA 01/2021
1	Sodium-Glucose Transporter 2 InhibitorsIBA 12/2020
1	Matrix Metalloproteinases (MMPs)IBA 10/2020
1	Metalloproteases (Metalloproteinases)IBA 10/2020
1	OvalbuminIBA 04/2020
1	Toll-Like Receptor 9IBA 02/2020
1	NF-kappa B (NF-kB)IBA 01/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020
1	Cyclic GMP-Dependent Protein Kinases (Protein Kinase G)IBA 01/2020
1	Scorpion Venoms (Scorpion Venom)IBA 01/2020
1	Anti-Obesity Agents (Antiobesity Drugs)IBA 01/2020
1	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)IBA 01/2020
1	lorcaserinIBA 01/2020

Therapy/Procedure

5	Therapeutics 10/2016 - 02/2008